FOREWORD

The concept for gathering together and publishing pertinent information
on the physical and chemical properties of various official and new drug
substances had its origin with the members of the Section on Pharmaceutical
Analysis and Quality Control of the Academy of Pharmaceutical Sciences.
More than two years of consideration preceded the authorization of this
ambitious project by the Executive Committee of the Academy in the Spring
of 1970. The immediate and virtually spontaneous enlistment of the first
group of contributors t o this work attested t o its importance and the wisdom
of pursuing its publication.
By coincidence, the delegates t o the sesquicentennial anniversary meeting
of the United States Pharmacopeial Convention, Inc., in Washington, D.C.
on April 8-1 0, 1970, adopted the following resolution:
Whereas widespread interest has been expressed in the inclusion of additional
information about physical and chemical properties of drugs recognized in the
United States Pharmacopeia
Be It Resolved that the Board of Trustees consider publishing in the
Pharmacopeia, or in a companion publication, information on such attributes as
solubilities, pH and pK values, spectra and spectrophotometric constants, and
stability data, pertaining to pharmacopeial drugs.
The U.S.P.C. Board of Trustees unanimously approved the resolution in
principle on June 4, 1970 and authorized the Director of Revision t o include
in the U.S.P. monographs such physical-chemical information as he deemed
proper and also to cooperate with the Academy of Pharmaceutical Sciences
to secure the publication of other physical-chemical data.
It was my privilege to be the President of the Academy during the
period when Arialyticai Profiles was under consideration. I t is my unusual
and unique honor as President of the Academy and Director of U.S.P.
Revision to assist in the institution and dedication of this first volume. I trust
that it will serve immeasurably in providing the scientific community with an
authoritative source of information on the properties of many of our important
drug compounds.

January 1971 Thomas J. Macek

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