Preface from the author:

It is now well over a decade that I perceived the need to supplement the official
compendial standards of drug substances with a comprehensive review of pertinent
physical, chemical, and analytical data and methods. Ten years ago the first
volume of Analytical Profiles of Drug Substances was published under the auspices
of the Pharmaceutical Analysis and Control Section of the APhA Academy of Pharmaceutical
Sciences. That we were able to publish one volume per year is a tribute
to the diligence of the editors to solicit monographs and even more so to the enthusiastic
response of our authors, an international group associated with pharmaceutical
firms, academic institutions, and compendial authorities. I would like
to express my sincere gratitude to them for making this venture possible.
I am pleased to report that five years ago a companion series entitled Pharmacological
and Biochemical Properties of Drug Substances was initiated by Morton
E. Goldberg under the auspices of the section on Pharmacology and Toxicology,
APhA Academy of Pharmaceutical Sciences. So far, three volumes have
been published.
Over the years, we have had queries concerning our publication policy. Our
goal is to cover all drug substances of medical value and, therefore, we have
welcomed any monographs of interest to an individual contributor. We also have
endeavored to solicit profiles of the most useful and used medicines, but many in
this category still need to be profiled.
Starting with this, the eleventh volume, we shall also supplement previously
published profiles with new data as we can find volunteers to write such supplements.
In this volume, five of the original profiles in Volume 1 have been updated.
The goal to cover and update all drug substances of medical value with comprehensive
monographs is still a distant one. I estimate that only about a quarter of
such compounds have been profiled so far. We would very much like to accelerate
the rate of publication and hope that even more authors can be encouraged to
write profiles. All those who have found these profiles useful are requested to contribute
monographs of their own. We, the editors, stand ready to receive such contributions.

Klaus Florey

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