PREFACE

Although the official compendia list tests and limits for drug substances
related to identity, purity, and strength, they normally d o not provide other
physical or chemical data, nor do they list methods of synthesis or pathways
of physical or biological degradation and metabolism. For drug substances
important enough t o be accorded monographs in the official compendia such
supplemental information should also be made readily available. To this end
the Pharmaceutical Analysis and Control Section, Academy of Pharmaceutical
Sciences, has undertaken a cooperative venture t o compile and publish
Analytical Profiles of Drug Substances in a series of volumes of which this is
the fourth.
The concept of Analytical Profiles is taking hold not only for compendial
drugs but, increasingly, in the industrial research laboratories. Analytical
Profiles are being prepared and periodically updated to provide physico-chemical
and analytical information of new drug substances during the consecutive
stages of research and development. Hopefully then, in the not too distant
future, the publication of an Analytical Profile will require a minimum of
effort whenever a new drug substance is selected for compendia] status.
The cooperative spirit of our contributors had made this venture possible.
All those who have found the profiles useful are earnestly requested to
contribute a monograph of their own. The editors stand ready to receive such
contributions.
This volume of Analytical Profiles is dedicated to the memory of David
E. Guttman, an enthusiastic member of the Editorial Board until his tragic
and untimely death in 1974.

Klaus Florey

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