Chronic Obstructive Pulmonary Disease - Cellular and Molecular Mechanisms (Lung Biology in Health and Disease)

Chronic Obstructive Pulmonary Disease - Cellular and Molecular Mechanisms (Lung Biology in Health and Disease)

Description:
Emphasizing the urgent need to clearly understand the underlying cellular and molecular mechanisms involved in Chronic Obstructive Pulmonary Disease ( COPD ), this reference provides an up-to-date perspective on the inflammatory cells, mediators, and molecular pathology of Chronic Obstructive Pulmonary Disease ( COPD ). With chapters by international authorities on the subject, this reference presents advances in our understanding of cellular mechanisms, cell signaling, and gene expression relevant to Chronic Obstructive Pulmonary Disease ( COPD ), new approaches that may prevent the progression of Chronic Obstructive Pulmonary Disease ( COPD ), research on corticosteroid resistance in Chronic Obstructive Pulmonary Disease ( COPD ), and studies on the development of new pharmaceuticals to control the underlying inflammatory and damaging processes that trigger Chronic Obstructive Pulmonary Disease ( COPD ). This book reiterates traditional knowledge regarding epidemiology, perturbations of respiratory structure and function, and natural history of chronic obstructive pulmonary disease. The most significant elements offered by contributors, however, emphasize how more recent research might facilitate the evolution of novel therapeutic interventions to favorably affect the outcomes presently seen. In aggregate, a comprehensive attempt is made to adopt observations made since the last edition in the molecular and cellular biology of respiratory structure and function, especially as regards immunology, inflammation, and repair, to forecast what avenues might be taken to minimize, block, or reverse the events seen in a macrocosm of this disease. It is the editor's intent to combine independent observations within microcosmic processes seen in the laboratory, and by inference, speculate about how, in combination and acting in the intact human organism, they might potentially underlie and result in clinical observations already so familiar. Admittedly, such an endeavor would not permit "connection of all the dots," not just because the number and origin of contributors is so eclectic, but simply because, by its nature, the more elements in human molecular and cellular biology become characterized, the more deficiencies in knowledge become apparent. Nonetheless, the science is far more elaborately explored than two decades ago. Most significantly, the monograph attempts to yoke basic science and clinical pulmonology in a manner uncommonly observed before. Pulmonologists and researchers in this field as well as trainees in pulmonary medicine allergy and immunology and critical care are the intended audience. The detailed handling of basic molecular and cellular respiratory biology makes this text unsuited for the casual reader. The monograph focuses primarily on the molecular and cellular biology believed to underlie the evolution of chronic obstructive pulmonary disease, most notably what has been learned during the last two decades about immunology, inflammation, and repair - about cells, their differentiation, and their products, about immunoglobulins, mediators of various types, especially those that facilitate "inter-cellular" communication, and about what "fibrosis" means. Finally, attention is paid to historically appreciated comorbidities associated with, or complications of, chronic obstructive pulmonary disease (e.g., weight loss, "exacerbations," and pulmonary vaso-destructive events), attempting to provide biologic bases for such observations not hitherto well explained.

Click Download below and Your Download will start on new tab.
Please click ads to keep this service free.
Download