Five-Lipoxygenase Products in Asthma (Lung Biology in Health & Disease) (Lung Biology in Health and Disease)



Description:
Five-Lipoxygenase Products in Asthma offers an authoritative examination of the biochemistry, basic pharmacology, and clinical pharmacology of the leukotrienes with special emphasis on their role in asthma.A critical reference for every asthma researcher and clinician, Five-Lipoxygenase Products in Asthma·
highlights agents and products of the 5-LO pathway and its relationship to other pathways·explores the enzymology of the 5-LO pathway with focus on leukotriene transport, degradation, and excretion·details the role of protein identification in the 5-LO pathway·describes human cell types that produce leukotrienes and their activation·outlines pharmacological and binding study evidence for leukotriene receptors·discusses the recovery of leukotrienes in lung disease·analyzes leukotriene receptor antagonists and synthesis inhibitors by specific agent·provides a by entity summary of individual drug information in exercise-induced, allergen-induced, aspirin-induced, and chronic stable asthma·profiles the use of agents active on the 5-LO pathway in asthma treatment·and more!With complete discussions of the recovery of leukotrienes in induced and spontaneous asthma and other conditions, Five-Lipoxygenase Products in Asthma, will benefit pulmonologists and pulmonary disease specialists; clinical allergists; internists; chest, intensive care, primary care, and family practice physicians; respiratory therapists; physiologists; pathologists; cell and molecular biologists; and graduate and medical school students in these disciplines. This book, a cutting edge review of the 5-lipoxygenase pathway and its inhibitors in asthma, is another volume in the Lung Biology in Health and Disease series, whose executive editor is Claude Lenfant. The editors state that this book's purpose is to provide a state-of-the-art review of the 5-lipoxygenase pathway, and more importantly, a discussion of how it can be specifically interrupted to provide a therapeutic effect in asthma. These worthy objectives are met very well by this volume. This book is written for investigators who need the most current information on the 5-lipoxygenase pathway. It would also be a useful reference for clinicians who care for a significant number of asthma patients. The editors and contributors are generally recognized as international experts in their field. The first part is a detailed review of the basic science of the 5-lipoxygenase pathway including cellular and molecular biology, while the second half reviews clinical application of inhibition of the 5-lipoxygenase pathway. A unique feature of the book is that it provides reviews of each of the available 5-lipoxygenase pathway or receptor inhibitors currently used in asthma therapy. This is a useful compendium of state-of-the-art reviews of the 5-lipoxygenase pathway, both basic and clinical science. It would be of obvious interest to researchers in asthma and would be a useful reference for clinicians. Thus, medical libraries would be well advised to make it alvailable.

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